Combination Potions Review

What are combination potions? Like the name implies, they combine the effects of certain potions into one dose. Some are useless, but most others have extremely useful effects and can be much, much better than conventional potions.

There are 22 combination potions in total, but before you can make a potion, you must buy the recipe from the Meilyr clan, either from the workers or Lady Meilyr herself. Prices range from 100k to 1000k. 9 of those recipes, however, are lost; to unlock them, you need to go Dungeoneering after talking to Lady Meilyr about the missing recipes to randomly receive a recipe as an item on the floor, much like Dungeoneering keys. A recipe has a chance to spawn every time you open a door, and the chances of it appearing increase by 10% per level, bringing it to 1/320 at 120 Dungeoneering. Hard Mode floors triple the drop rate, so it increases up to 1/107 at 120. Only one recipe can spawn per floor.

Recipes are also available from consistent yak cards randomly received from the Gorajo hoardstalker in the 95 Dungeoneering resource dungeon in the Meilyr clan (guarantees one recipe per dungeon) and the motherload maw from the 115 Dungeoneering resource dungeon (randomly gives items to help with normal/trimmed completionist capes once per day). Finally, recipes can be simply bought from the reward trader for 500k tokens.

Creating combination potions requires a crystal flask (can be created from the Ithell clan) and 4-dose potions. The end result is a 6-dose potion. This raises up an interesting observation: you basically convert 4-dose potions to 6-dose flasks, which means you gain doses, saving money overall! As a result, almost all of these combination potions are more cost-effective than the conventional potions, barring a few exceptions.

As for the potions themselves, let’s take a closer look.

  • Grand potions

Ingredients: Super attack/strength/ranging/magic/defence + attack/strength/ranging/magic/defence
Prices: 100k

These come in grand attack, strength, defence, ranging, and magic ptions, and serve as the mid-point between super and extreme potions. For comparison, at a 99 stat, supers boost up to 112 and extremes boost to 116. Grand potions are right in-between at 114. The main selling point, however, is that they’re tradable, so they’re automatically a better choice over supers, provided the player in mind has a lower Herblore level. Overall, they’re just like any other single-stat potions we’re all familiar with, just the next best tradable option now.

  • Super Melee (requires Dungeoneering)

Ingredients: Super defence + attack + strength
Price: 150k

This potion is a super attack, strength, and defence in one. Though it’s tradable, it’s ultimately pointless because grand potions exist. Avoid using this and just cough up more money for grand potions.


  • Super warmaster’s potion

Ingredients: Super attack + strength + ranging + magic + defence
Price: 200k

Think the super Melee potion, but for all styles and not just Melee. It’s still not worth using over grand potions, so again skip these. However, they do have a tiny niche for Dagannoth Kings for those who don’t have overloads, so if you want to do Dagannoth Kings but lack the Herblore level for overloads, this is a decent choice.

  • Replenishment potion

Ingredients: Adrenaline potion + Super restore
Price: 200k

A combination of an adrenaline potion and super restore, these are extremely useful. In addition to acting as an adrenaline potion, it restores Prayer points and drained stats alongside, and who can say no to free Prayer alongside using an adrenaline potion? I know I can’t.

  • Wyrmfire potion

Ingredients: Super antifire + antifire
Price: 200k

A super antifire that protects against skeletal wyverns’s ice breath as well. I personally say “meh”, but if you kill lots of skeletal wyverns, it may be helpful. Even then, however, if you use Magic and stand far away enough, they won’t use their ice breath, so even with that perk, it’s limited. Avoid this potion.


  • Extreme brawler’s, sharpshooter’s, battlemage’s, and warmaster’s potion (requires Dungeoneering)

Ingredients: Extreme attack + strength + defence / Extreme ranging + defence / Extreme magic + defence / Extreme attack + strength + ranging + magic + defence
Prices: 300k (brawler’s, sharpshooter’s, battlemage’s)/400k (warmaster’s)

Think the above super melee and warmaster’s potions, except for extremes. The names correspond to the style they reference, and the warmaster’s variant is a melting pot of them all – basically, an overload that doesn’t refresh boosts. Not too useful as they’re just trailing behind overloads in level requirements.

  • Supreme potions

Ingredients: Extreme attack/strength/ranging/magic/defence + super attack/strength/ranging/magic/defence
Prices: 500k

But hold on! In addition to the above, we’re pushing the level limits with the next level of potions beyond extremes. These are the single-stat potions we know, and with a 99 stat, they boost up to 118. Not a bad jump at all, even though it’s only 2 levels. Despite that, though, these single-stat boosting potions aren’t worth making. Why? Well, read on.

  • Brightfire potion

Ingredients: Prayer renewal + Super antifire
Price: 600k

A cross between a Prayer renewal and super antifire, this is exactly what it says on the tin. This is useful at QBD, but not for much else. If you make these, keep at a low supply.


  • Super Prayer renewal potion

Ingredients: Prayer renewal + Prayer potion
Price: 750k

This is probably my second favorite combination potion, as this is a cross between a Prayer renewal and potion. You can probably guess why I love it from that description alone; this means an insane amount of Prayer restore per dose – the initial Prayer restore and the even better renewal effect. That’s simply amazing, but the thing that seals the deal is that it’s cheaper than normal Prayer renewals and tradable. If you’re still using normal renewals, stop now and switch! You won’t regret it at all.

  • Holy overload

Ingredients: Overload + Prayer renewal
Price: 700k

A mesh between a Prayer renewal and overload. It’s a great potion for places you’re planning to camp for a long, long time to conserve inventory space like Dagannoth Kings and GWD bosses. Slayer is also a great place to use them, since it’s at such a cheap price. Not much else to say.

  • Searing overload

Ingredients: Overload + Super antifire
Price: 700k

Combination of super antifire and overloads. Again, like brightfire potions, they’re good for QBD, but I also find good use for them with dragon tasks when doing Slayer, as I normally use the demon horn necklace + bonecrusher combination for unlimited Prayer.

  • Overload salve (requires Dungeoneering)

Ingredients: Overload + Super antifire + Antifire + Prayer renewal + Prayer potion + Super antipoison
Price: 800k

This is quite the interesting combination. With this salve, it’s a combination of a wyrmfire, super antipoison, super Prayer renewal, and overload potion, all in one. That’s quite the protection against a variety of sources, even though the only place that would be nice to have them all is KBD (poison and dragonfire). It’s just there for convenience against dragons or Araxxor (poison), but it’s still hilariously impractical to use. Stick to other combinations.

  • Supreme overload

Ingredients: Overload + super attack + strength + ranging + magic + defence
Price: 900k

Behold: my favorite combination potion out of the bunch! Basically, it’s an overload with the boost of a supreme potion. Obviously as the next level up for combat boosts, these are extremely useful for top-end PvM, and the super Prayer renewal and supreme overload combination may even be better than holy overloads in inventory management! Though it would also be expensive in price…

  • Supreme overload salve (requires Dungeoneering)

Ingredients: Supreme overload + Super antifire + Antifire + Prayer renewal + Prayer potion + Super antipoison
Price: 1000k

Basically an overload salve, but has the boost of a supreme overload instead of a normal overload. That’s it. However, this is better off over normal overload salves as it’s basically the only way to get the super Prayer renewal effect with the supreme overload like holy overloads. It also comes with extra benefits like antipoison and antifire as normal, so overall it’s the “best” potion in the game, but impractical in majority of instances.

  • Perfect plus (requires Dungeoneering)

Ingredients: Overload + harmony moss + crystal tree blossom
Price: 1000k

Unlike every other potion on the list, this is not a combat potion. Rather, this is a skilling potion with some benefits at Prifddinas. You get 3% bonus XP under the Voice of Seren, and gain the effects of all of the perfect juju potions, which are as follows:

– Perfect Woodcutting: 5% chance of double logs/chops from trees/ivy
– Perfect Farming: 25% chance of double harmony moss when fully harvesting from a harmony pillar, 5% chance of getting moss from checking a fully grown patch
– Perfect Mining: 10% chance of summoning a stone spirit to auto-smelting and banking of ores when mining and 10% bonus XP obtaining ores for the next few minutes
– Perfect Smithing: 10% chance of corrupted ore when smithing bars
– Perfect Agility: Guaranteed chance of one of two shortcuts to appear on Hefin Agility Course
– Perfect Prayer: 5% more XP from gilded altars and cleansing Seren stones
– Perfect Herblore: 10% additional chance to getting a Dungeoneering recipe when Dungeoneering (boosts to 1/291 chance at 120 Dungeoneering and 1/97 at Hard Mode), 5% more XP from making combination potions
– Perfect Dungeoneering: 5% bonus damage within Dungeoneering, and all skill doors within require two levels lower

Each dose lasts for 4 hours straight. Go nuts.

That covers all combination potions. I hope you learned a thing or two regarding these new additions to Herblore. Have fun and make sure you put some of these to use!

~ Evil Lucario

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